Clotrimazole ointment what to smear. Clotrimazole ointment

Compound

1 g of cream contains:

active substance: clotrimazole 0.01 g

Excipients: benzyl alcohol, cetostearyl alcohol, octyldodecanol, polysorbate 60, sorbitan stearate, synthetic cetaceum (ester cetyl wax), purified water.

Description

Homogeneous mass of white.

Pharmacotherapeutic group

Antifungal agents for external use. Derivatives of imidazole and triazole. The codeATX: [ D01 AC01] .

pharmachologic effect

Clotrimazole inhibits cell growth and division and, depending on the concentration, may have a fungistatic or fungicidal effect. Clotrimazole changes the permeability of the cell membrane by disrupting the synthesis of ergosterol and binding to the phospholipids of the fungal cell wall. Clinical studies have shown that topical treatment of infections with clotrimazole is as effective as other imidazole derivatives such as econazole and ketoconazole.

Clotrimazole inhibits the synthesis of proteins, fats, DNA and polysaccharides, damages cellular nucleic acids and accelerates the excretion of potassium. It can also inhibit the activity of oxidases and peroxidases and the biosynthesis of triglycerides and phospholipids in fungi. At higher concentrations, clotrimazole causes damage to cell membranes through mechanisms independent of sterol synthesis. Clotrimazole prevents the transformation of Candida blastospores albicans into an invasive mycelium. A change in the activity of the cell membrane leads to cell death and depends on the degree of drug exposure to microbial organisms.

Activity spectrum

Clotrimazole is characterized by a wide spectrum of activity. Clotrimazole inhibits the development and destroys dermatophytes (Epidermophyton floccosum, microsporum canis, Trichophyton mentagrophytes, Trichophyton rubrum), yeast (Candida spp., Cryptococcus neoformans) and dimorphic fungi (Coccidioides immitis, Histoplasma capsulatum, Paracoccidioides brasiliensis). Also, clotrimazole is active against some gram-positive (Streptococcus, Staphylococcus, Gardnerella vaginalis) and gram negative (Bacteroides) microorganisms.

In vitro clotrimazole inhibits reproduction Corynebacterium and gram-positive cocci (with the exception of enterococci) at concentrations of 0.5-10 µg/ml.

Clotrimazole has a wide spectrum of fungistatic and fungicidal activity in vitro. Its effect on the mycelium of dermatophytes (Trichophyton, microsporum, Epidermophyton) similar to the action of griseofulvin, and the effect on budding fungi (Candida) similar to the activity of polyenes (amphotericin B and nystatin).

Clotrimazole at a concentration below 1 μg / ml inhibits the development of most strains Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum and microsporum canis. Clotrimazole at a concentration of 3 μg / ml inhibits the development of most pathogens Pityrosporum orbiculare, Aspergillus fumigatus, Candida species, including Candida albicans, some strains Staphylococcus aureus and Streptococcus pyogenes, as well as some strains Proteus vulgaris and Salmonella. Clotrimazole works against Sporothrix, Cryptococcus, Cefalosporium and Fusarium. Concentrations above 100 µg/ml are effective against Trichomonas vaginalis.

Mushrooms resistant to clotrimazole are extremely rare; there is data only for individual strains Candida guilliermondii.

No development of resistance has been reported in clotrimazole-sensitive fungi after passage. Candida albicans and Trichophyton mentagrophytes. There are no cases of development of resistance to clotrimazole in strains WITH.albicans, resistant to polyene antibiotics due to chemical mutation.

Pharmacokinetics

When applied topically to the skin, clotrimazole is absorbed by the epidermis. Higher concentrations of clotrimazole are found in the horny and spinous layers of the epidermis, as well as in the papillary and reticular layers of the dermis, however, clotrimazole enters the systemic circulation in small quantities.

Clotrimazole is metabolized in the liver to inactive substances excreted from the body through the kidneys and intestines.

Indications for use

Clotrimazole cream is used for topical treatment

Fungal diseases of the skin: hands and feet, trunk, lower leg and foot, caused by dermatophytes Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum and microsporum canis; pityriasis versicolor caused by Malassezia furfur (Pityrosporum orbiculare or Pityrosporum ovale) ;

Fungal infections of the skin and mucous membranes of the external genitalia (labia, foreskin and glans penis) caused by Candida vulvitis or Candida balanitis.

Contraindications

Hypersensitivity to clotrimazole or excipients of the drug.

Use during pregnancy and lactation

Pregnancy

There are limited data on the use of clotrimazole during pregnancy. Animal studies have not shown a direct or indirect effect on reproductive toxicity. As a precautionary measure, the use of clotrimazole in the first trimester of pregnancy should be avoided.

Lactation

Available pharmacodynamic/pharmacokinetic data in animals have shown excretion of clotrimazole/metabolites into milk. During treatment with clotrimazole, breastfeeding should be discontinued.

Fertility

Studies of the effect of clotrimazole on human fertility have not been conducted. Animal studies have shown no effect on fertility

Dosage and administration

For outdoor use.

The cream should be applied in a thin layer 2-3 times a day on previously cleansed (using neutral pH soap) and dry affected areas for 2-4 weeks.

The cream should be applied simultaneously to all affected areas.

When applying the cream on the feet, they must be thoroughly washed, dried, and then applied to the areas between the toes.

Patients should re-consult a doctor if symptoms do not improve after 7 days of treatment.

Side effect

The frequency of occurrence of adverse reactions is defined as follows: very often (≥ 1/10), often (from ≥ 1/100 to the frequency is unknown (frequency cannot be estimated from the available data).

Immune system disorders:

Frequency unknown: allergic reactions (such as urticaria, shortness of breath, arterial hypotension, fainting).

Skin and subcutaneous tissue disorders:

Frequency unknown: itching, rash, blisters, peeling of the skin, sensation of pain or discomfort, swelling, burning, irritation, erythema, tingling.

If the listed adverse reactions occur, as well as reactions not mentioned in the instructions for medical use, you should contact your doctor.

Overdose

With external use of the drug, an overdose is unlikely.

The use of clotrimazole in high doses does not cause any reactions and conditions that are life-threatening.

The drug is not intended for oral administration. If by chance the cream is taken orally, anorexia, nausea, vomiting, abdominal pain, liver dysfunction are possible; rarely drowsiness, hallucinations, frequent urination, allergic skin reactions. In this case, it is necessary to carry out a gastric lavage and prescribe activated charcoal.

In case of accidental contact of the cream with the eyes or mouth, immediately rinse them with water and consult a doctor as soon as possible.

If the cream is swallowed, you should immediately consult a doctor.

From fungal diseases, antifungal tablets or external agents are prescribed. To treat such problems, you can use Clotrimazole in the form of an ointment.

Clotrimazole - description

Clotrimazole is an antimycotic (antifungal) ointment for local use in dermatology, gynecology. The tool is available in different packages - 10-50 g each. Among the companies that produce it are Akrikhin (the drug Clotrimazole-Acri is produced), Teva, ETS Pharma, GlaxoSmithKline, Pharmtechnologies and others.

How much the drug costs will depend on the manufacturer. Russian funds are sold at a price of 20-70 rubles, among Polish, Indian, German medicines the cost is higher -100-250 rubles.

The active ingredient of the composition is clotrimazole in the amount of 10 mg.

Ointment (cream) can only be used externally. It is white with a yellowish tint, thick, but not greasy. The smell of the drug is specific. As additional components, the ointment includes:

Clotrimazole is produced not only in the form of an ointment. There are other forms on sale, for example, a 1% alcohol solution, a 1% gel. A vaginal form is also produced - tablets for local use, which are conveniently used for gynecological diseases in women.

The action of the drug

Clotrimazole has a wide spectrum of action, it is effective against a large number of fungal species. The antimycotic effect of clotrimazole, which is an imidazole derivative, is due to a violation of the most important processes in the fungal cell. The active substance negatively affects the synthesis of ergosterol, a component of cell membranes. As a result, membrane permeability becomes higher, which provokes lysis and cell death.

The drug acts fungicidal and fungistatic, depending on the amount of the applied substance.

Clotrimazole also acts by another mechanism, which only increases its effectiveness. When interacting with cell enzymes, the substance causes an increase in the concentration of hydrogen peroxide. The level of the latter becomes toxic, fungal particles are destroyed.

In the form of an ointment, Clotrimazole helps against diseases caused by such mycoses:

Also, the drug helps against the causative agent of erythrasma - corynebacterium, which does not belong to mycotic, but to bacterial cells. As an antimicrobial agent, Clotrimazole can be used against staphylococci and streptococci, trichomonas, and a number of gram-negative bacteria.

The tool does not give a systemic effect, its penetrating power is low. During treatment, clotrimazole is poorly absorbed through the skin, mucous membranes, but it can accumulate in the stratum corneum of the nails. In the dermis, subcutaneous tissue, clotrimazole is almost not detected.

Main indications

This tool has a variety of indications related to different fields of medicine. In the form of an ointment, Clotrimazole is used for dermatitis caused by fungal pathogens, with mycotic diseases:

The most active drug manifests itself against dermatophytes and yeast fungi. With its help, you can get rid of dermatomycosis, mycotic paronychia, canidomycosis, skin microsporia, trichophytosis and epidermophytosis. The medicine quickly heals fungal erosions, which most often appear on the interdigital spaces in men and women. Also, Clotrimazole ointment is effective against fungi on the legs.

Due to its ability to act on bacteria, the ointment can be applied to skin with mycosis that has been affected by a secondary bacterial infection. Usually this is observed with secondary pyoderma, which occurs in conjunction with mycosis. Outwardly, the ointment is used for such pathologies:

In women, the drug can be used for thrush - vaginal candidiasis, for vulvovaginal candidiasis, for trichomoniasis (in combination therapy with systemic agents). In men, the drug is applied to the genitals with candidal balanitis, balanoposthitis.

Side effects, contraindications

The drug is usually well tolerated. Due to the lack of systemic absorption, only local side effects are possible, which manifest themselves as itching, red spots, rash, tingling, burning. Most often, burning and itching are observed with intravaginal use. Usually, withdrawal from therapy is not required, unpleasant phenomena quickly pass. In rare cases, the development of a local form of urticaria is possible. Also among the unpleasant reactions are rarely observed:

In the treatment of candidiasis in women, frequent urination sometimes appears. In case of an overdose during intravaginal application, there is a risk of abdominal pain, diarrhea, headaches (in isolated cases).

During pregnancy in the 1st trimester, it is better not to use any medications, only if absolutely necessary. But according to indications, treatment in pregnant women is possible, since in experiments clotrimazole did not have a negative effect on the fetus. During lactation, it is forbidden to smear the skin of the breast, therapy on other parts of the body is allowed. Children under 2 years of age are not treated with ointment, as with liver diseases in the terminal stage. It makes no sense to treat herpes with this remedy - the ointment does not help with viral pathologies.

Instructions for use

The medicine can be used exclusively externally and intravaginally. With mycotic lesions of the feet, open areas of the skin, the procedure for therapy is as follows:

A single dosage should not exceed 5 cm column of ointment, this rate is indicated for an area the size of the palm of an adult. It is necessary to use the remedy regularly, omissions of therapy help to reduce the reactivity of the infection to the active component. Treatment is carried out until the symptoms disappear completely, plus 3-5 days, with a fungus of the skin of the feet, an additional 14 days should be treated. Usually the course lasts 10-28 days depending on the type of infection. With a combination of bacterial and fungal infections, the course is 1 month. Erythrasma usually disappears in 2-3 weeks, with pityriasis versicolor, 1-3 weeks are treated.

On the recommendation of a doctor, the ointment can be used to treat oral thrush (although a solution is usually used for this purpose). Processing is done 1-2 times a day, the maximum course is 7 days. The ointment is injected into the vagina on a swab or with the help of an applicator in the same doses once a day at night. The course from thrush, trichomoniasis - 5-6 days.

Thrush or vaginal candidiasis is a disease that affects both the female and male genital organs. It begins through the penetration of fungal infections.

To combat this type of disease, one of the effective pharmacological drugs called Clotrimazole is used. What is this ointment, what are the main indications for its use, as well as reviews of women who have experienced the effectiveness of the remedy for themselves.

Clotrimazole ointment for thrush in women is a white thick consistency, which is applied directly to the genitals. It consists of such a basic substance as clotrimazole (0.01 g), as well as auxiliary components: paraffin, which makes the ointment white, cetostearyl alcohol, sodium dihydrogen phosphate, purified water, chlorcresol. The drug was created to combat fungal spores of various origins. It is used mainly for candidiasis of the female and male genital organs.

In addition to treatment, the ointment can be applied for fungal manifestations of the feet, skin, and mucous cavities. Clotrimazole is quite effective for the treatment of the following types of diseases:

candidiasis;
trichomoniasis;
erythrasma;
stomatitis;
dermatophytosis.

The main active ingredient in the composition of the cream contributes to the complete destruction of fungal spores of dimorphic, mold and yeast-like origin. The ointment limits the synthesis of nucleic acid, as well as ergosterol in infected cells. Through the negative effect of the drug on fungal formations, cells are damaged and completely destroyed.

Clotrimazole ointment is used to fight a fungus that provokes the development of microsporia and lichen. The pharmacological agent has long proved its high degree of effectiveness, but in order to overcome the disease, you will need to undergo a course of treatment ranging from 5 to 10 days. The duration depends on the form of the disease and the degree of complication, and the effectiveness of the impact is due to the correct use of the drug.

Features of the use of Clotrimazole ointment

Ointment Clotrimazole is available in a tube with a capacity of 20 grams. It is forbidden to independently treat thrush in women, especially if you are not sure of the accuracy of the diagnosis. Initially, at the first symptoms of vaginal candidiasis, which manifests itself by the appearance of redness, burning and itching in the genital area. With such symptoms, you need to contact a gynecologist or dermatologist, who, on the basis of research, will make a diagnosis and prescribe the appropriate treatment.

From thrush, Clotrimazole ointment is used in this way:

the cream must be applied in a thin layer into the vagina;
the number of rubbing is once a day;
the duration of treatment is three days.

Before using Clotrimazole ointment, it is necessary to carry out hygiene procedures, which include taking a bath or shower. This is necessary in order to exclude infection in the vaginal cavity. Clotrimazole ointment must be used carefully and correctly, for this, the cream is rubbed in a circular motion. The approximate dose for single use is about 5 grams.

Read also: The use of diflucan for thrush in women

When you find out about the disease, you need to give up sexual contact for the period of treatment. A regular sexual partner should also undergo an examination to exclude symptoms of the disease. Often, if one of the partners has signs of candidiasis, then the second one will also have them after a few days. Men use a cream to treat candidiasis, for which its consistency should be applied to the foreskin and head of the penis. The duration of treatment is from 5 to 10 days.

Side effects of the drug

If, after applying Clotrimazole ointment, women develop symptoms of irritation and allergic manifestations, then the use of the drug should be stopped immediately. The main negative results after using the ointment include the following manifestations:

itching in the vaginal cavity;
burning;
puffiness;
peeling of the skin;
allergic rash;
irritation;
inflammatory process.

If one of the above signs occurs, then the use of Clotrimazole ointment from thrush should be excluded. Side effects may occur due to the following reasons:

intolerance by the body of one and the constituent components of the ointment;
with improper use of the drug;
with an overdose.

Local use of the drug for thrush eliminates the development of side symptoms. During pregnancy, it should be used with great caution, and categorically excluded during the first trimester. In order to avoid a negative effect on the fetus, it is recommended to use Clotrimazole in the form of a cream or suppositories. If the drug causes side symptoms, then you should look for another remedy for the treatment of thrush, in which your doctor will help you.

Contraindications

Clotrimazole ointment has a number of contraindications, which are due to the negative effect of the composition of the drug on the woman's body. If she has signs of intolerance to the ointment, then its use on the same day should be excluded.

To prevent unpleasant consequences in the first trimester of pregnancy, it is required to avoid the use of Clotrimazole in any form of release. It is allowed to start treatment no earlier than from the 12th week of pregnancy. During lactation, clotrimazole should be used with caution. The most favorable form of removing candidiasis during breastfeeding is a cream or ointment.

The only thing that is important to know is the categorical ban on the treatment of the mammary glands with Clotrimazole during breastfeeding. Substances of the drug can enter the baby's body, causing it to be poisoned or intoxicated.

Treatment of thrush

You can cure thrush or vaginal candidiasis with Clotrimazole. But such therapy will be less effective compared to the complex use of drugs and procedures. What this approach includes, we will find out further.

When treating thrush, it is important to carry out hygiene procedures. This is the basis not only for recovery, but also for the prevention of many diseases. Before using Clotrimazole ointment, it is necessary to wash yourself with solutions from medicinal decoctions on herbs. No less effective are drugs such as furacillin or potassium permanganate.
Carry out douching procedures. This is done in order to exclude the development of the inflammatory process, relieve swelling and remove the remnants of secretions. Douching is carried out with the help of medicines and herbal infusions.
Hygiene procedures in the form of taking a cold shower, as well as dipping the genitals in herbal infusions. Women are advised to stop wearing synthetic underwear, which will improve the ventilation of the genitals. If during treatment you have critical days, it is recommended to stop using tampons. It is best to use gaskets, which should be changed as often as possible.
In parallel with the treatment of candidiasis with Clotrimazole, women need to strengthen their immunity. This will not only allow you to recover sooner, but also to avoid the appearance of the disease in the future.
Most diseases are caused by malnutrition. Avoid fast foods, exclude the use of flour products, fatty foods, as well as sweets and salty foods. This will restore shape and get rid of vaginal candidiasis sooner.

Clotrimazole ointment is intended for the treatment of fungal infections. The tool has a detrimental effect on many types of pathogenic microorganisms. The effective element of the drug penetrates the cell membrane and stops the development of the disease.

Clotrimazole is used in the complex treatment of various infections of the skin caused by excessive reproduction of Corynebacterium minutissimum and Malasseria furfur.

Due to the easy method of use, a large percentage of the active substance in the composition and good tolerance on the part of patients, Clotrimazole has found wide application in the treatment of fungal infections.

The active substance of the product is clotrimazole - 1 g of the product contains 10 mg (the account is kept on a dry matter of 100%). The composition of the ointment also includes additional substances:

polyethylene glycol acetostraryl alcohol;
propylene glycol;
cetosteryl alcohol;
polyethylene glycol 400;
proxanol 268.

The ointment is almost transparent, with a homogeneous consistency and a specific smell.

Release form Clotrimazole

The ointment is produced in the form of an aluminum tube (30 g, 20 g) with bushes having an internal lacquer coating. The tube is packaged in paper packaging. A leaflet is attached to the product - an insert with instructions for use and storage conditions.

Clotrimazole is also available in the form of:

vaginal tablets. Parallelepiped-shaped tablets with slightly rounded corners. Contains 100 mg of active substance. Each blister contains 6 dragees.
Cream. The cream has a white color and a uniform consistency, intended for external use. The amount of the active element in this form is 10 mg per 1 g of the product. The cream is packaged in tubes of 30 g, 20 g. Vaginal cream (2%) is produced in tubes of 50 g.
Solution for external use. It has a soft texture like an emulsion. A solution (1%) is produced in ampoules of 15 or 30 ml. Has a white or slightly orange color.
Candles. Vaginal suppositories have a cylindrical shape. Color - white or with a yellow tint.

The product must not be frozen. You can store 3 years from the date of issue, at a temperature of 25 degrees.

Action

Clotrimazole belongs to a number of antifungal drugs with a wide spectrum of action. The active component of the product is clotrimazole, which has a destructive effect on various pathogenic microorganisms (dermatophytes, yeasts and molds), including dimorphic fungi and actinomycetes of the genus Nocardia.

The agent has a fungistatic, and with respect to dermatophytes and fungi of the genus Candida - a fungicidal effect.

Due to the property of the active substance to be quickly absorbed into the skin, when using the product, the fastest possible effect on the causative agent of the disease occurs. The skin under the influence of the drug is cleansed, its surface is leveled, the normal functioning of the affected organs is restored.

The active substance is able to penetrate the tissues of the placenta and appear in the body of the fetus. Given this fact, use Clotrimazole ointment during pregnancy or if you suspect it should be used with caution, only with the permission of a doctor, in case of emergency.

When using Clotrimazole ointment in high concentrations on problem areas of the skin, an increase in the effectiveness of exposure is observed.

Excretion of the decay products of the drug occurs through the kidneys.

The effect on resistant strains is rarely recorded. Clotrimazole has antibacterial properties against certain gram-positive cocci and corynebacteria. At certain concentrations, it has a trichomonacid effect. The active substance of the agent blocks the synthesis of nucleic acids, proteins and ergosterol in fungal cells, thereby causing the death of pathogenic microorganisms.

According to clinical studies, it is stated that the drug has practically no systemic effect.

Indications for use

Clotrimazole ointment has an antifungal effect, also actively acting on other pathogens that are dangerous to health.

Clotrimazole ointment is used for:

Thrush in men and women (candidiasis balanitis and vulvitis);
Paronycheia (inflammation of the periungual roller);
stomatitis;
Combinations of infections of candidiasis and trichomoniasis;
Dermatophyte;
Skin infections on the trunk and in the inguinal zone;
Detection of a fungal disease of the outer ear;
Mycoses;
coccal infections;
Trichomonas;
Pitiriase;
Psoriasis;
Erytheme;
Erythrasma (bacterial lesion of the skin in the areas of folds);
Completed hemorrhoids.

Often the remedy is used to treat herpes zoster, pityriasis, ringworm and color deprivation. Fungi that cause infection are sensitive to the active substance of the drug and are quickly destroyed when used.

Clotrimazole is also used for severe pigmentation. Clotrimazole copes with both herpes and streptoderma.

Side effects

When applying Clotrimazole ointment, you need to apply it to a small area and check the reaction of the body. The following side effects occur:

In areas where the product is applied, irritations, allergic reactions are possible in the form of:

peeling;
skin redness;
urticaria;
tingling and itching;
burning sensation;
blister formation.

Headaches, gastrointestinal upset;

Frequent urination (in the treatment of genital candidiasis).

Contraindications

The main contraindication to the use of the drug is hypersensitivity to the components of the drug.

Pregnancy (first months);
Use of alcohol and antibiotics;
Under the age of 12;
Liver diseases;
Menstrual cycle in case of vaginal administration.

Interaction with other medicines

Clotrimazole ointment may reduce exposure to:

Nystatin;
Amphotericin;
Natamycin.

A negative reaction when interacting with other medicines should not be expected, since the resorption capacity of clotrimazole is rather low.

Instructions for use

Clotrimazole ointment is intended for external use. Apply the product to the previously washed and dried problem area. It is allowed to clean the area of application of the agent with a soap that has a neutral effect. Rub the ointment with massaging movements until completely absorbed. The usual rate is 3 times a day.

The duration of the course is determined by the severity of the disease and the localization of the infection.

With dermatoses, the average course duration is about 4 weeks. With pityriasis versicolor - 3 weeks. With a fungal infection of the skin of the lower extremities, therapy should be continued for another 15 days after the symptoms disappear.

When treating nail fungus, both the nail plate and the skin around the finger should be treated. During the treatment of a fungal infection of the lower extremities, you need to wear tights, socks, shoes made of natural material so that the skin can breathe freely. It is also very important to observe the rules of hygiene, frequent change of socks.

After the first manifestations of recovery, experts advise continuing to use the ointment for another two weeks in order to strengthen the result.

It is necessary to treat a fungal infection with Clotrimazole ointment only in a full course, without interrupting treatment, even if acute symptoms recede.

If the next application of the ointment is missed, the treatment of the affected area should be carried out as soon as possible.

If a pronounced improvement in the condition of the skin after 4 months of using the product is not observed, you need to consult a dermatologist and introduce an adjustment to the therapeutic course of treatment.

Instructions for use Clotrimazole for men

The main percentage of diseases caused by a fungal infection are lesions of the genital organs. Among the male population, there is a problem in the form of thrush (candidiasis balanitis). The disease is caused by fungi of the genus Candida. The infection is transmitted sexually.

Symptoms of candidiasis are:

burning sensation and itching on the genitals;
pain during urination;
discomfort during sexual intercourse;
swelling, rash on the genitals;
discharge with an unpleasant odor.

Clotrimazole ointment has been successfully used to treat such an infection. Already from small doses, the disease begins to recede, further use leads to the death of the pathogen in 7 days. During the treatment period, loose cotton underwear should be worn.

The ointment is used topically, 2 times a day in the morning and at bedtime. Apply the ointment to the head of the penis, the foreskin.

Special Instructions

Before you start using Clotrimazole ointment, you should carefully read the instructions, especially with the special instructions in it:

With a fungal infection of the skin of the mammary gland during lactation, the use of the drug is not allowed;
The use of ointment in the first and second trimester of pregnancy is allowed only on the recommendation of a doctor;
This drug should not be used to treat a fungal infection of the skin around the eyes;
Do not apply the product to the mucous membranes and eyes. If the drug accidentally gets into these areas, they should be washed off as quickly as possible with plenty of running water;
With the appearance of pronounced local side reactions, the use of the ointment should be discontinued;
After working with the drug, wash your hands with warm water and soap;
The drug does not affect the functions of the brain, does not have a systemic effect on the body.

Cases of overdose are not registered.

Analogues

Substitute means of Ointment Clotrimazole are:

Candide;
Imidil;
Antifungol;
Akrikhin ointment;
Amyclone;
Candibene.

In the instructions for use of Clotrimazole ointment, it is recommended to use it for the treatment of thrush in women. The disease develops with a sharp decrease in immunity and is manifested by severe symptoms. Particular discomfort is caused by pain and burning, pain in the lower abdomen, vaginal discharge. The use of systemic antimycotic agents often leads to adverse reactions. Therefore, doctors prescribe women drugs for topical use.

Clotrimazole ointment is often included in the therapeutic regimens of patients with thrush (vaginal candidiasis). It not only eliminates the symptoms, but also affects the cause of the disease - Candida yeast-like fungi. The drug is available, it is not expensive, it is convenient for treatment at home.

Clotrimazole ointment is a time-tested remedy against thrush. This infection of the genital organs often develops with endocrine pathologies, hypothermia, and prolonged use of antibiotics. With the weakening of the body's defenses, pathogens of mycoses begin to become more active. Candida fungi belong to the opportunistic microflora and are always present in the vagina in small quantities. Against the background of a decrease in immunity, they begin to multiply rapidly and affect the mucous membranes. If at this stage you use Clotrimazole ointment, then you can do without taking systemic antimycotics. The drug quickly eliminates the symptoms of thrush:

burning and itching in the vagina;
redness, swelling, itching;
pain during and after urination;
curdled discharge from the genitals.

The drug helps to quickly get rid of the symptoms of chronic vaginal candidiasis. With this form of pathology, there is rarely a discharge of thick mucus from the vagina. Women suffer from excessive dryness of the mucous membrane, hyperemia, dry erosion.

Even after a single application of an antifungal agent, the intensity of clinical manifestations decreases.

To enhance the therapeutic effect of the ointment, the doctor may prescribe the simultaneous use of other drugs. The action of Clotrimazole is enhanced by immunomodulators, immunostimulants, balanced complexes of vitamins and microelements.

Pharmacotherapeutic group and action

Clotrimazole ointment is used for the effective treatment of genital candidiasis. Its antifungal action is based on the pharmacological properties of the active ingredient, an imidazole derivative. To build cell membranes, pathogenic fungi produce the organic compound ergosterol. Clotrimazole blocks enzymes that stimulate its biosynthesis and prevents the spread of infection. Under the action of the ointment, the permeability of the membranes changes, so the cell gradually dissolves. The drug exhibits antimycotic activity against such pathogenic fungi:

dermatophytes;
yeast-like and mold fungi;
causative agents of multi-colored lichen.

When using the drug in small doses, it has a fungistatic effect, preventing damage to healthy tissues. And the frequent use of Clotrimazole ointment in large quantities helps to completely destroy the pathogens of thrush. The active ingredient enters into biochemical reactions with enzymes, increasing the concentration of hydrogen peroxide. Such an environment is toxic to fungi, causing the destruction of their cells.

After applying the product to the vaginal mucosa, about 5-10% of the active substance of the ointment is absorbed. It is metabolized by liver cells and evacuated from the human body along with bile.

Release form, composition and packaging

On the pharmacy counters there is Clotrimazole ointment from Russian, Indian Polish manufacturers. The products of domestic pharmaceutical factories are much cheaper, varying between 20-30 rubles. The price of an imported drug can exceed 80-100 rubles. The drug is produced in the form of a 1% ointment of a jelly-like consistency without a characteristic odor. In addition to the active ingredient, it contains the following auxiliary chemical compounds:

propylene glycol;
polyethylene oxide;
methylparaben;
nipagin;
cetostearyl alcohol;
glycerol
Castor oil;
distilled water.

Auxiliary components enhance and prolong the clinical action of Clotrimazole. They create a pH environment as close as possible to the acidity of human skin and mucous membranes. Propylene glycol ensures maximum absorption of the active ingredient, its uniform distribution in tissues. And castor oil moisturizes the mucous membranes, accelerating their regeneration. Cetostearyl alcohol is added to the composition, from which Clotrimazole ointment helps women eliminate unbearable itching.

The external agent is packaged in aluminum tubes of 15.0 g, 20.0 g, 30.0 g, 40.0 g. The secondary packaging is a cardboard box with instructions for use enclosed inside.

Instructions for use for women

To start using Clotrimazole ointment in women with thrush should be at the first clinical manifestations. During the treatment of vaginal candidiasis, it is necessary to refuse sexual intercourse. Otherwise, there is a high risk of re-infection from a partner.

The instructions for use of Clotrimazole ointment in gynecology recommend the simultaneous use of drugs to increase immunity. With a low resistance of the body, a new relapse of thrush is possible. The use of immunostimulants with an antimycotic agent (Immunal, echinacea tinctures, ginseng) will completely get rid of the disease.

Indications for use

Doctors prescribe Clotrimazole in the form of an ointment for the treatment of vaginal candidiasis at any stage of the pathology. It is used both for therapy and as a prophylactic. The drug for application to the vaginal mucosa destroys fungal pathogens and prevents exacerbations of thrush.

Clotrimazole ointment relieves a woman of severe discomfort - burning from itching in intimate places.

It is appointed by gynecologists and for the following purposes:

prevention of activation of pathogenic fungi while taking systemic antibacterial drugs;
prevention of the development of thrush in women with immunodeficiency conditions.

Clotrimazole ointment is injected into the vagina before childbirth when vaginal candidiasis is detected in the mother. It sanitizes the mucous membranes and prevents infection of the child during passage through the birth canal.

Clotrimazole for thrush

This is one of the most affordable and commonly used remedies for the treatment of vaginal candidiasis. The therapeutic line of Clotrimazole includes: solution, cream, gel, vaginal suppositories and tablets. When diagnosing thrush of moderate and high severity, drugs are combined. The combination worked well:

tablets for insertion into the vagina and preparations for application to the mucous membranes;
vaginal suppositories with cream or gel.

In the treatment of complicated thrush in women, the doctor prescribes for the rapid elimination of symptoms: Clotrimazole and Fluconazole. This technique can significantly speed up recovery and avoid relapses against the background of reduced immunity.

The use of Clotrimazole ointment for thrush in women is suspended during menstruation. At this time, you can use vaginal tablets or suppositories. Doctors strongly recommend refraining from douching during the treatment of candidiasis, which contribute to the spread of infection. Be sure to treat the sexual partner with antimycotics for external and internal use.

Contraindications and side effects

An absolute contraindication to the use of any dosage form of Clotrimazole is individual sensitivity to the components. It may not be the active ingredient, but substances used to form tablets or creams. An external agent should be used with caution in the presence of severe pathologies of the liver and urinary organs. Side effects of the drug include:

burning and hyperemia;
swelling of the epithelium;
the appearance of rashes.

After intravaginal use of Clotrimazole, in addition to the above symptoms, in rare cases, urination becomes more frequent. Swelling and hyperemia of the mucous membranes causes a feeling of dryness and itching. Ingoda increases the volume of curdled vaginal discharge. After consultation with a gynecologist, it is possible to adjust the dosages or replace the drug with an analogue.

Use during pregnancy and lactation

Clotrimazole ointment, gel or cream for thrush is prescribed by gynecologists only in the 2nd and 3rd trimesters of pregnancy. According to the results of clinical trials in the later stages, the drug does not have a teratogenic effect. Despite the relative safety during therapy, the patient is shown regular laboratory blood control.

A small amount of the active ingredient enters the systemic circulation. There is a possibility of its accumulation in breast milk. Therefore, it is better not to use any dosage forms of Clotrimazole during breastfeeding.

Dosage and administration

Daily and single doses for vaginal administration of Clotrimazole are determined by the attending physician. Equally important are the stage of the course of the pathology and the degree of damage to the mucous membranes. The average dose is approximately 5 mm of the product squeezed out of the tube. How to use Clotrimazole ointment or cream for thrush in women:

before the treatment procedure, it is necessary to wash the genitals with hygiene products and dry with a towel;
apply the ointment not only to the area of inflammation, but also to adjacent healthy tissues.

Depending on the stage of the pathology and the number of developed complications, gynecologists recommend using the drug 1-3 times a day.

You can not stop treatment after the disappearance of symptoms of vaginal candidiasis. Therapy is carried out until the absence of pathogens is established in the biological sample. To prevent the development of adverse reactions, it is necessary to dose the medicine correctly.

Application features

Clotrimazole for the treatment of the intimate area is used as monotherapy or as part of a complex treatment. During its use, you should stop wearing synthetic underwear. The following medical recommendations will help speed up recovery:

the use of 2-2.5 fluids daily to remove the products of the inflammatory process from the body;
exclusion from the diet of foods high in sugar, provoking the rapid reproduction of pathogenic fungi.